N Wagner

Latest

• beta7 integrin controls immunogenic and tolerogenic mucosal B cell responses.
• Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.
• Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice.
• Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
• Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.
• Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis.
• Monoclonal antibody against beta7 integrins, but not beta7 deficiency, attenuates intestinal allograft rejection in mice.
• Beta7 integrins contribute to skin graft rejection.
• beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis.
• Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response.
• Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production.
• alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus.
• Despite high levels of lymphocyte homing receptor alpha4beta7 integrin after small bowel allotransplantation, it is not critical for rejection.
• Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice.
• Beta7 integrins contribute to demyelinating disease of the central nervous system.
• Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection.
• The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response.
• Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.
• L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
• The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.
• Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.
• Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.