W Muller

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• IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation.
• Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons.
• Permeability analyses and three dimensional imaging of interferon gamma- induced barrier disintegration in intestinal organoids.
• Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses.
• Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.
• Exclusive dependence of IL-10Ralpha signalling on intestinal microbiota homeostasis and control of whipworm infection.
• Macrophage-Specific NF-kappaB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients.
• The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Depends on Host Genetic Background.
• Distinct Roles for CD4(+) Foxp3(+) Regulatory T Cells and IL-10-Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani.
• Evaluating the IgMi mouse as a novel tool to study B-cell biology.
• Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.
• Interleukin-1beta has atheroprotective effects in advanced atherosclerotic lesions of mice.
• Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors.
• Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation.
• IL-6-Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion.
• Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency.
• Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease.
• Gamma Interferon Mediates Experimental Cerebral Malaria by Signaling within Both the Hematopoietic and Nonhematopoietic Compartments.
• Involvement of interleukin-1 type 1 receptors in lipopolysaccharide- induced sickness responses.
• Guidelines for the use of flow cytometry and cell sorting in immunological studies.
• Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.
• TGF-beta inhibitor Smad7 regulates dendritic cell-induced autoimmunity.
• P2X7 receptor-dependent tuning of gut epithelial responses to infection.
• IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells.
• CD4(+) Th2 cells are directly regulated by IL-10 during allergic airway inflammation.
• Constitutive Kit activity triggers B-cell acute lymphoblastic leukemia- like disease in mice.
• Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity- Mediated Inflammation and Insulin Resistance.
• Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.
• Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes.
• T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation.
• Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.
• Myeloid interferon-gamma receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.
• Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.
• Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo.
• Erratum to: Making sense of big data in health research: towards an EU action plan.
• Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.
• Mesenteric Fat Lipolysis Mediates Obesity-Associated Hepatic Steatosis and Insulin Resistance.
• Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells.
• Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.
• IFNgamma signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells.
• Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response.
• Extracellular vesicles from neural stem cells transfer IFN-gamma via Ifngr1 to activate Stat1 signaling in target cells.
• Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer.
• Protective mucosal immunity mediated by epithelial CD1d and IL-10.
• Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
• Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
• Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function.
• IFN-gamma-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.
• Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days.
• Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.
• Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation.
• TGF-beta signalling is required for CD4(+) T cell homeostasis but dispensable for regulatory T cell function.
• Neuroprotective intervention by interferon-gamma blockade prevents CD8+ T cell-mediated dendrite and synapse loss.
• A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.
• T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice.
• CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function.
• T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine.
• IL-10 acts as a developmental switch guiding monocyte differentiation to macrophages during a murine peritoneal infection.
• beta7 integrin controls immunogenic and tolerogenic mucosal B cell responses.
• Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.
• Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection.
• IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
• Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates.
• B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.
• Induction of regulatory T cells by a murine beta-defensin.
• Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivo.
• Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.
• Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus.
• gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis.
• Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.
• Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
• Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation.
• Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways.
• Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.
• Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.
• Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.
• TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells.
• Transgenic mice with a diverse human T cell antigen receptor repertoire.
• Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.
• Differential roles of macrophages in diverse phases of skin repair.
• Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model.
• Pillars article: A critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831.
• Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors.
• Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation.
• Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10.
• Charles River altered Schaedler flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages.
• Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice.
• Nonredundant roles for B cell-derived IL-10 in immune counter-regulation.
• T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection.
• Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies.
• The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.
• A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
• IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.
• Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.
• Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation.
• Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion.
• Conditional gp130 deficient mouse mutants.
• Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease.
• Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.
• GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
• Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
• Mast cell-specific Cre/loxP-mediated recombination in vivo.
• Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.
• Susceptibility of four inbred mouse strains to a low-pathogenic isolate of Yersinia enterocolitica.
• Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots.
• LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.
• Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.
• Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
• Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes.
• Serum response factor contributes selectively to lymphocyte development.
• Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1.
• The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens.
• Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man.
• Mouse Phenotype Database Integration Consortium: integration $[$corrected$]$ of mouse phenome data resources.
• Dissecting the cytokine network.
• Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA.
• VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.
• Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.
• A change of expression in the conserved signaling gene MKK7 is associated with a selective sweep in the western house mouse Mus musculus domesticus.
• Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice.
• gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor.
• Nine fluorescence parameter analysis on a four-color fluorescence activated flow cytometer.
• Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.
• Virus free, cell-based assay for the quantification of murine type I interferons.
• Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.
• Introducing the German Mouse Clinic: open access platform for standardized phenotyping.
• T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
• Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.
• Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte- expressed protein.
• The European dimension for the mouse genome mutagenesis program.
• CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis.
• The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.
• Lack of gp130 expression in hepatocytes promotes liver injury.
• Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development.
• Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases.
• IL-15 is an essential mediator of peripheral NK-cell homeostasis.
• Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis.
• Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration.
• Monoclonal antibody against beta7 integrins, but not beta7 deficiency, attenuates intestinal allograft rejection in mice.
• beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis.
• Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.
• Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response.
• Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production.
• Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons.
• alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus.
• Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor.
• Despite high levels of lymphocyte homing receptor alpha4beta7 integrin after small bowel allotransplantation, it is not critical for rejection.
• Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice.
• Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen.
• Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally.
• Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection.
• Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response.
• The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response.
• Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.
• Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice.
• IMGT, the international ImMunoGeneTics database.
• Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.
• Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects.
• L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
• The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.
• Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation.
• c-fos expression interferes with thymus development in transgenic mice.
• IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.
• IMGT, the International ImMunoGeneTics database.
• IMGT, the international ImMunoGeneTics database: a new design for immunogenetics data access.
• Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains.
• Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.
• Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.
• On the role of the common cytokine receptor gamma chain in B-cell vs. T-cell development.
• Gene targeting in immunology.
• A T cell clone which responds to interleukin 2 but not to interleukin 4.
• Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.
• IMGT, the international ImMunoGeneTics database.
• Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.
• Plasmodium chabaudi chabaudi: differential susceptibility of gene- targeted mice deficient in IL-10 to an erythrocytic-stage infection.
• Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.
• Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.
• Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
• Conditional gene targeting.
• Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
• Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.
• In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
• T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.
• Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.
• Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.
• Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
• A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
• Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
• Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice.
• A genetic approach for the analysis of cytokine function in vivo.
• Altered immune responses in mice lacking inducible nitric oxide synthase.
• Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
• Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.
• Interleukin 10 inhibits interleukin 6 production and acute phase response in rheumatoid arthritis.
• Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.
• Leishmania major and Toxoplasma gondii have opposite effects on cytokine synthesis by macrophages.
• Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide.
• Resistance to murine acquired immunodeficiency syndrome (MAIDS)
• Analysis of the B-cell progenitor compartment at the level of single cells.
• Lymphocyte populations and immune responses in CD5-deficient mice.
• Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.
• Early B-cell development in the mouse: insights from mutations introduced by gene targeting.
• Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
• Interleukin-4-deficient mice.
• Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.
• Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection.
• Interleukin-10-deficient mice develop chronic enterocolitis.
• Long-term consequences of interleukin-6 overexpression in transgenic mice.
• T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.
• A critical role of lambda 5 protein in B cell development.
• Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction.
• Generation of long-lived B cells in germ-free mice.
• Most peripheral B cells in mice are ligand selected.
• Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.
• Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia.
• Generation and analysis of interleukin-4 deficient mice.
• CD5 B cells in the mouse.
• Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity.
• High gradient magnetic cell separation with MACS.
• Membrane-bound IgM obstructs B cell development in transgenic mice.
• A retroviral expression vector containing murine immunoglobulin heavy chain promoter/enhancer.
• Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.
• A new V gene expressed in lambda-2 light chains of the mouse.
• Cell-cooling in flow cytometry by Peltier elements.
• Lymphokines regulate immunoglobulin isotype expression in an antigen- specific immune response.
• Control of immunoglobulin class switch recombination.
• Signal requirements for growth and differentiation of activated murine B lymphocytes.
• Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response. I. Isotype distribution.
• Intercellular communication and cell cooperation in growth control of T-lymphocytes.